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這種在血漿和尿液中發(fā)現(xiàn)的二肽是在谷胱甘肽分解代謝過程中產(chǎn)生的。半胱氨酰甘氨酸已被建議誘導(dǎo)氧化應(yīng)激和脂質(zhì)過氧化,導(dǎo)致人類癌癥的發(fā)展。
編號:181988
CAS號:19246-18-5
單字母:H2N-CG-OH
編號: | 181988 |
中文名稱: | 二肽Cys-Gly |
英文名: | Cys-Gly |
CAS號: | 19246-18-5 |
單字母: | H2N-CG-OH |
三字母: | H2N N端氨基:N-terminal amino group。在肽或多肽鏈中含有游離a-氨基的氨基酸一端。在表示氨基酸序列時,通常將N端放在肽鏈的左邊。 -Cys半胱氨酸:cysteine。L-半胱氨酸的系統(tǒng)命名為(2R)-氨基-3-巰基丙酸,是編碼氨基酸。符號:C,Cys。D-半胱氨酸存在于螢火蟲的螢光素酶中。 -Gly甘氨酸:glycine。系統(tǒng)命名為 2-氨基乙酸。是編碼氨基酸中沒有旋光性的最簡單的氨基酸,因具有甜味而得名。符號:G,Gly。 -OHC端羧基:C-terminal carboxyl group。在肽或多肽鏈中含有游離羧基的氨基酸一端。在表示氨基酸序列時,通常將C端放在肽鏈的右邊。 |
氨基酸個數(shù): | 2 |
分子式: | C5H10N2O3S1 |
平均分子量: | 178.21 |
精確分子量: | 178.04 |
等電點(diǎn)(PI): | - |
pH=7.0時的凈電荷數(shù): | 1.94 |
平均親水性: | -1 |
疏水性值: | 1.05 |
外觀與性狀: | 白色粉末狀固體 |
消光系數(shù): | - |
來源: | 人工化學(xué)合成,僅限科學(xué)研究使用,不得用于人體。 |
純度: | 95%、98% |
鹽體系: | 可選TFA、HAc、HCl或其它 |
生成周期: | 2-3周 |
儲存條件: | 負(fù)80℃至負(fù)20℃ |
標(biāo)簽: | 二肽(Dipeptide) |
This dipeptide found in plasma and urine is generated during the catabolism of glutathione. Cysteinylglycine has been suggested to induce oxidative stress and lipid peroxidation, leading to the development of human cancers.
DOI | 名稱 | |
---|---|---|
10.1016/0003-2697(92)90456-h | Determination of the in vivo redox status of cysteine, cysteinylglycine, homocysteine, and glutathione in human plasma | 下載 |
10.1007/s00216-006-0454-x | Analysis of urine for cysteine, cysteinylglycine, and homocysteine by high-performance liquid chromatography | 下載 |
10.1007/s00726-007-0590-4 | High-throughput capillary electrophoresis method for plasma cysteinylglycine measurement: evidences for a clinical application | 下載 |
10.1158/0008-5472.CAN-07-3061 | Plasma cysteinylglycine levels and breast cancer risk in women | 下載 |
10.1271/bbb.70395 | Structural analysis of the fundamental polymer of the sheath constructed by Sphaerotilus natans | 下載 |
10.1016/j.jasms.2010.01.027 | Mobile protons versus mobile radicals: gas-phase unimolecular chemistry of radical cations of cysteine-containing peptides | 下載 |
10.1021/tx300045f | Hydrogen exchange equilibria in thiols | 下載 |
10.1111/mmi.12274 | Molecular and structural basis of glutathione import in Gram-positive bacteria via GshT and the cystine ABC importer TcyBC of Streptococcus mutans | 下載 |
10.3390/molecules19079552 | Formation of a flavin-linked peptide | 下載 |
10.1039/c5an00206k | Complementing reversed-phase selectivity with porous graphitized carbon to increase the metabolome coverage in an on-line two-dimensional LC-MS setup for metabolomics | 下載 |
10.1039/c5an01629k | An integrated metabolomics workflow for the quantification of sulfur pathway intermediates employing thiol protection with N-ethyl maleimide and hydrophilic interaction liquid chromatography tandem mass spectrometry | 下載 |
10.1002/anie.201506019 | Radical Formation in the Gas-Phase Ozonolysis of Deprotonated Cysteine | 下載 |
10.1074/jbc.M115.700989 | Peptide Bond Synthesis by a Mechanism Involving an Enzymatic Reaction and a Subsequent Chemical Reaction | 下載 |
10.1016/j.jmr.2016.10.003 | Robust conversion of singlet spin order in coupled spin-1/2 pairs by adiabatically ramped RF-fields | 下載 |
編號 | 名稱 | CAS號 |
197625 | 二肽Ac-Ala-Lys-NH2 | |
Ac-AK-CONH2 | ||