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LL-37, human 是一種由37 個(gè)氨基酸殘基組成的兩親性組織蛋白酶衍生的抗菌肽,具有廣泛的抗菌活性。
編號(hào):125937
CAS號(hào):154947-66-7
單字母:H2N-LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES-OH
LL-37, human 是一種由37 個(gè)氨基酸殘基組成的兩親性組織蛋白酶衍生的抗菌肽,具有廣泛的抗菌活性。它有助于保護(hù)角膜免受感染,對(duì)于傷口愈合有著良好的促進(jìn)作用,同時(shí)對(duì)多種革蘭氏陽(yáng)性和革蘭氏陰性病原體具有抗菌和抗生物膜活性。
LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.
LL-37是一種具有血管生成活性的抗菌肽。它對(duì)應(yīng)于人組織蛋白酶抗菌蛋白hCAP18/LL-37的C末端序列(134-170),并通過蛋白水解過程從hCAP18/LL-37細(xì)胞外釋放。hCAP18/LL-37是先天免疫系統(tǒng)的效應(yīng)器,在白細(xì)胞和上皮細(xì)胞中表達(dá),與炎癥和損傷相關(guān)上調(diào)??梢宰C明hCAP18/LL-37在一系列乳腺癌中的過表達(dá)。LL-37被認(rèn)為部分通過甲酰肽受體樣1(FPRL1)刺激上皮細(xì)胞增殖,因?yàn)橛冒偃湛榷舅刈钄嗍荏w會(huì)使LL-37的增殖作用降低約50%。
LL-37 is an antimicrobial peptide with angiogenic activity. It corresponds to the C-terminal sequence (134-170) of the human cathelicidin antimicrobial protein hCAP18/LL-37 and is extracellularly released from hCAP18/LL-37 by proteolytic processing. hCAP18/LL-37 is an effector of the innate immune system and is expressed in leukocytes and epithelial cells where it is upregulated in association with inflammation and injury. An overexpression of hCAP18/LL-37 in a series of breast carcinomas could be demonstrated. LL-37 has been suggested to stimulate epithelial cell proliferation partially through formyl peptide receptor-like 1 (FPRL1) since blocking the receptor with pertussis toxin decreased the proliferative effect of LL-37 by approximately 50 %.
DOI | 名稱 | |
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10.1016/j.bbamem.2006.03.030 | LL-37, the only human member of the cathelicidin family of antimicrobial peptides | 下載 |
10.1167/iovs.05-1649 | Multifunctional roles of human cathelicidin (LL-37) at the ocular surface | 下載 |
10.1371/journal.pone.0124706 | Antiviral Activity of the Human Cathelicidin, LL-37, and Derived Peptides on Seasonal and Pandemic Influenza A Viruses | 下載 |
10.1371/journal.pone.0133454 | Identifying the Critical Domain of LL-37 Involved in Mediating Neutrophil Activation in the Presence of Influenza Virus: Functional and Structural Analysis | 下載 |
10.1172/JCI17545 | An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 | 下載 |
10.1002/ijc.20795 | Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells | 下載 |
10.1152/ajplung.00286.2004 | Human endogenous antibiotic LL-37 stimulates airway epithelial cell proliferation and wound closure | 下載 |
10_1002cplu_202200240 | Self-Assembly of Linear, Natural Antimicrobial Peptides: An Evolutionary Perspective | 下載 |