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An inhibitor of dipeptidyl aminopeptidase IV.
編號：138690
CAS號：90614-48-5
單字母：H2N-IPI-OH
| 編號: | 138690 |
| 中文名稱: | 抑二肽素A、Diprotin A |
| 英文名: | Diprotin A |
| CAS號: | 90614-48-5 |
| 單字母: | H2N-IPI-OH |
| 三字母: | H2N N端氨基：N-terminal amino group。在肽或多肽鏈中含有游離a-氨基的氨基酸一端。在表示氨基酸序列時，通常將N端放在肽鏈的左邊。 -IleL-異亮氨酸：isoleucine。系統(tǒng)命名為(2S)-氨基-(3R)-甲基戊酸。是編碼氨基酸。有兩個手性碳原子，是哺乳動物的必需氨基酸。符號:I，Ile。 -ProL-脯氨酸：proline。系統(tǒng)命名為吡咯烷-(2S)-羧酸。為亞氨基酸。是編碼氨基酸。在肽鏈中有特殊作用，如易形成順式的肽鍵等。符號：P，Pro。 -IleL-異亮氨酸：isoleucine。系統(tǒng)命名為(2S)-氨基-(3R)-甲基戊酸。是編碼氨基酸。有兩個手性碳原子，是哺乳動物的必需氨基酸。符號:I，Ile。 -OHC端羧基：C-terminal carboxyl group。在肽或多肽鏈中含有游離羧基的氨基酸一端。在表示氨基酸序列時，通常將C端放在肽鏈的右邊。 |
| 氨基酸個數(shù): | 3 |
| 分子式: | C17H31N3O4 |
| 平均分子量: | 341.45 |
| 精確分子量: | 341.23 |
| 等電點(PI): | - |
| pH=7.0時的凈電荷數(shù): | 0.97 |
| 平均親水性: | -1.8 |
| 疏水性值: | 2.47 |
| 外觀與性狀: | 白色粉末狀固體 |
| 消光系數(shù): | - |
| 來源: | 人工化學(xué)合成，僅限科學(xué)研究使用，不得用于人體。 |
| 純度: | 95%、98% |
| 鹽體系: | 可選TFA、HAc、HCl或其它 |
| 生成周期: | 2-3周 |
| 儲存條件: | 負(fù)80℃至負(fù)20℃ |
| 標(biāo)簽: | 三肽 |
An inhibitor of dipeptidyl aminopeptidase IV.
| DOI | 名稱 | |
|---|---|---|
| 10.1016/j.foodchem.2012.02.183 | Production of dipeptidyl peptidase IV inhibitory peptides from defatted rice bran | 下載 |
| 10.1039/c4fo00983e | In vitro bioactive properties of intact and enzymatically hydrolysed whey protein: targeting the enteroinsular axis | 下載 |
| 10.1042/BJ20021643 | Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII | 下載 |
| 10.2337/diacare.26.3.837 | Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes | 下載 |
| 10.1128/AAC.49.3.1087-1092.2005 | Orally active antiviral tripeptide glycyl-prolyl-glycinamide is activated by CD26 (dipeptidyl peptidase IV) before transport across the intestinal epithelium | 下載 |
| 10.1111/j.1742-4658.2005.04631.x | The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity | 下載 |
| 10.1016/j.neuint.2006.05.006 | The effects of endomorphins and diprotin A on striatal dopamine release induced by electrical stimulation-an in vitro superfusion study in rats | 下載 |
| 10.1021/jm0606490 | Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach | 下載 |
| 10.1089/scd.2007.9997 | Diprotin A infusion into nonobese diabetic/severe combined immunodeficiency mice markedly enhances engraftment of human mobilized CD34+ peripheral blood cells | 下載 |
| 10.1016/j.peptides.2007.07.012 | Prolyl, cystyl and pyroglutamyl peptidase activities in the hippocampus and hypothalamus of streptozotocin-induced diabetic rats | 下載 |
| 10.33549/physiolres.931231 | Modulation of substance P signaling by dipeptidyl peptidase-IV enzymatic activity in human glioma cell lines | 下載 |
| 10.1152/ajpendo.90233.2008 | Incretin and islet hormonal responses to fat and protein ingestion in healthy men | 下載 |
| 10.1007/s11064-008-9853-z | The effects of endomorphins on striatal [3H]GABA release induced by electrical stimulation: an in vitro superfusion study in rats | 下載 |
| 10.1016/j.exphem.2009.03.005 | Enhanced homing and engraftment of fresh but not ex vivo cultured murine marrow cells in submyeloablated hosts following CD26 inhibition by Diprotin A | 下載 |
| 10.1038/oby.2009.378 | Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats | 下載 |
| 10.1210/jc.2011-0266 | Incretin hormone and insulin responses to oral versus intravenous lipid administration in humans | 下載 |
| 10.1016/j.biocel.2012.01.011 | Dipeptidyl peptidase-IV inhibits glioma cell growth independent of its enzymatic activity | 下載 |
| 10.1016/j.molmet.2013.11.010 | Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency | 下載 |
| 10.1210/jc.2014-3865 | Incretin effect after oral amino acid ingestion in humans | 下載 |
| 10.1186/s13098-015-0075-7 | Probiotic B420 and prebiotic polydextrose improve efficacy of antidiabetic drugs in mice | 下載 |
| 10.7164/antibiotics.37.422 | Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria | 下載 |
| 10.1016/s0014-5793(98)00515-8 | Rat dipeptidyl peptidase IV (DPP IV) exhibits endopeptidase activity with specificity for denatured fibrillar collagens | 下載 |
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